The Night Synthesis
closeup of smear of cream-colored skincare night cream, on white background
The Night Synthesis
Two images of a man's brow from The Night Synthesis clinical trials. Image on the top displays man's brow before using The Night Synthesis, and the image on the bottom shows his brow after using The Night Synthesis for four weeks.
Two side-by-side images of a woman's cheek from The Night Synthesis clinical trials. Image on the left displays woman's cheek before using The Night Synthesis, and the image on the right shows her cheek after using The Night Synthesis for four weeks.
Bio-Theriac Complex: fights signs of again and sensitivity. Nasturtium officinale and urtica dioica extracts: help protect against environmental stressors. Squalane: moisturizes and restores elasticity.
The Night Synthesis
closeup of smear of cream-colored skincare night cream, on white background
The Night Synthesis
Two images of a man's brow from The Night Synthesis clinical trials. Image on the top displays man's brow before using The Night Synthesis, and the image on the bottom shows his brow after using The Night Synthesis for four weeks.
Two side-by-side images of a woman's cheek from The Night Synthesis clinical trials. Image on the left displays woman's cheek before using The Night Synthesis, and the image on the right shows her cheek after using The Night Synthesis for four weeks.
Bio-Theriac Complex: fights signs of again and sensitivity. Nasturtium officinale and urtica dioica extracts: help protect against environmental stressors. Squalane: moisturizes and restores elasticity.
Rated 4.8 out of 5
Based on 53 reviews

The Night Synthesis

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Restructuring concentrate

Martha Stewart's Beauty recommends Dr. Rossi's The Night Synthesis.

Size 50 mL
−
+
FREE SHIPPING ON ALL ORDERS!

SUSTAINABLE BEAUTY

ALWAYS TESTED ON SENSITIVE SKIN

PARABEN, FRAGRANCE, AND DYE-FREE

DERMATOLOGIST APPROVED

CERTIFIED CRUELTY FREE

Approved and recognized by The North American Contact Dermatitis Society

This clinically proven age-defying concentrate harnesses the transformative power of Bio-Theriac® complex in a buttery texture that works with your skin while you sleep to visibly reduce the number and severity of fine lines and wrinkles while helping calm irritation. Our 2024 Best Seller.

Top 3 Reasons Why:

  1. Cellular repair occurs at night while we sleep
  2. Locking moisturize onto the skin at night helps to decrease transepidermal water loss and restore the skin barrier 
  3. Active ingredients are allowed to do their job because they are in contact for an extended period of time 

Appropriate for all skin types, including sensitive, dry, combination, and oily.

Bio-Theriac® complex

Dr. Rossi’s proprietary ingredient composite harnesses the power of biomimetic sea anemone peptide, niacinamide, and hyaluronic acid in a unique, optimized ratio to help fight the visible signs of premature aging caused by sensitization in skin.

Nasturtium Officinale and Urtica Dioica Extracts

Studies show that these watercress and nettle leaf extracts have high antioxidant activity, helping shield skin against environmental stressors which can lead to premature aging.  

Squalane 

One of nature’s greatest emollients, this plant-based, lab-fermented squalane helps prevent moisture loss while helping smooth skin and restore elasticity.

All Ingredients: Aqua/Water/Eau, Ethylhexyl Olivate, Cocos Nucifera (Coconut) Oil, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Niacinamide, Glycerin, Cetyl Alcohol, Glyceryl Stearate Citrate, Butylene Glycol, Persea Gratissima (Avocado) Oil, Maltodextrin, Polyglyceryl-3 Stearate, Hydrogenated Lecithin, Caprylyl Glycol, 1,2-Hexanediol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Squalane, Hydroxyacetophenone, Sodium Hyaluronate, Sodium Hydroxide, Sodium Phytate, Nasturtium Officinale Flower/Leaf/Stem Extract, Phenethyl Alcohol, Equisetum Arvense Extract, Urtica Dioica (Nettle) Extract, Pentapeptide-59, Tocopherol, Ethylhexylglycerin, Sodium Chloride

Gently massage onto face and neck before bed. Use nightly.

Goes well with

The Eye Cure

The Eye Cure

15 mL

$130.00

 

As seen in

CLINICAL TRIAL RESULTS

AFTER 4 WEEKS
BEFORE
AFTER 4 WEEKS:
  • 87% Agree Skin Feels More Supple and Elastic*
  • 87% Agree Skin Feels Healthier and Energized*
  • Up to 100% Smoother Skin*
  • Up to 100% Reduction in Redness*

*In a clinical study on 31 men and women 

WHY DR. ROSSI?

SENSITIVE SKIN, SPECIAL CARE

Dr. Rossi embarked on a mission to rethink skin care and create de-aging solutions appropriate for all, regardless of age, gender, or level of skin sensitivity. His goal: To combat the signs of skin aging while suppressing sensitization.

After treating both those patients battling cancer and those seeking cosmetic treatments, Dr. Rossi noticed that when his patients looked better, they felt better and healed more quickly. But his patients with sensitive skin couldn’t get the results they wanted because products in the market aggravated their sensitivity.

THE BREAKTHROUGH

Dr. Rossi developed his landmark formulas with his proprietary Bio-Theriac® complex, which helps correct the visible effects of aging and environmental aggressors while reducing sensitization. Dr. Rossi’s formulas exclude the use of ingredients that neither support skin health nor aid in its appearance, such as irritants, fillers, and fragrance.

The result is a relentlessly perfected and tested, revolutionary line of luxury treatments that will reveal your healthiest looking, most vibrant skin regardless of your gender identity, complexion, or skin condition. 

NEXT-GENERATION MEDICAL-GRADE SKIN CARE

"Skin sensitivity is not just discomfort—it can be tied to one of the root causes of premature skin aging. What we put on our skin matters, so if a product causes irritation it’s a big red flag and you’re probably doing more harm than good to your skin. I created this line of clean, high-performing products to restore skin to its youthful, healthy look while remaining non-irritating and safe to use on all skin types, including on the skin conditions of my cancer patients. This type of medical-grade skin care has never been done before."

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average rating 4.8 out of 5
Based on 53 reviews
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53 Reviews
Reviewed by Briana I., from United States
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
25 - 34
Rated 5 out of 5
Review posted

Glowy

One of my favorite moisturizers to date! I struggle with red acne scars and texturized skin, but this moisturizer has helped me regain my confidence and treat my complicated skin. I have also noticed a difference in the strength of my skin which feels more tight and glowy. I can now achieve the natural makeup look I've wanted my whole life because of how amazing this moisturizer is.

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Reviewed by Sharalyn, from United States
Verified Buyer
I recommend this product
Skin Type
Dry
Age Range
65+
Rated 5 out of 5
Review posted

Night Synthesis

I am 72 years old and found this night cream to be the best I’ve ever used ! I can definitely see an improvement in my fine lines and my skin feels so smooth in the morning. This cream along with the eye cure are amazing !!

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Reviewed by Dana, from United States
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
35 - 44
Rated 5 out of 5
Review posted

Incredible!

This is gold! I've never used anything like this before & my face looks and feels incredible after using Night Synthesis

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Reviewed by Arielle H., from United States
Verified Buyer
I recommend this product
Rated 5 out of 5
Review posted

Revised review

My original night synthesis dried out in packaging or transport and I was sent a replacement! Thank you so much. It’s wonderful!!

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Reviewed by Michael B., from United States
Verified Buyer
I recommend this product
Age Range
35 - 44
Rated 5 out of 5
Review posted

Instant Vibrant

Applied at night and woke up with radiant looking skin like I just got a facial. Product worked wonders and is now my go to every night!

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