Dr. Rossi Derm MD The Catalyst age-defying serum in black bottle on white background
closeup of two droplets of translucent skincare serum on white background
Bio-Theriac Complex: fights signs of aging and sensitivity. Saccharide blend: boosts hydration. Tamarindus Indica seed gum: helps promote smoother skin.
Two side-by-side images of a woman&
Two images of a woman&
Dr. Rossi Derm MD The Catalyst age-defying serum in black bottle, travel size
Dr. Rossi Derm MD The Catalyst age-defying serum in black bottle on white background
closeup of two droplets of translucent skincare serum on white background
Bio-Theriac Complex: fights signs of aging and sensitivity. Saccharide blend: boosts hydration. Tamarindus Indica seed gum: helps promote smoother skin.
Two side-by-side images of a woman's cheek from The Catalyst clinical trials. Image on the left displays woman's cheek before using The Catalyst, and the image on the right showsher cheek after using The Catalyst for four weeks.
Two images of a woman's brow from The Catalyst clinical trials. Image on the top displays woman's brow before using The Catalyst, and the image on the bottom shows her brow after using The Catalyst for four weeks.
Dr. Rossi Derm MD The Catalyst age-defying serum in black bottle, travel size

The Catalyst

Intense Renewing Serum

Rated 4.6 out of 5
Based on 53 reviews
$198.00
/

Size
Description

This transformative silky daily serum, packed with Bio-Theriac® complex, is clinically proven to help even tone while delivering visibly smoother skin. While combatting skin sensitivity, this serum significantly boosts skin firmness and measurably diminishes the appearance of fine lines and wrinkles.

Appropriate for all skin types, including sensitive, dry, combination, and oily. 

Bio-Theriac® complex

Dr. Rossi’s proprietary ingredient composite harnesses the power of biomimetic sea anemone peptide, niacinamide, and hyaluronic acid in a unique, optimized ratio to help fight the visible signs of premature aging caused by sensitization in skin.

Saccharide Blend 

This specially curated blend of saccharides, or sugars, works in tandem with hyaluronic acid to help lock moisture into the skin, boosting and maintaining hydration.  

Tamarindus Indica Seed Gum

Extracted from tamarind seeds, this potent plant derivative has been shown to help promote smoother skin and, with its well documented antioxidant properties, help prevent visible signs of premature aging.

All Ingredients:  Aqua/Water/Eau, Butylene Glycol, Sea Water (Maris Aqua), Glycerin, Niacinamide, Xylitylglucoside, Anhydroxylitol, Maltodextrin, Hydroxyethylcellulose, Propanediol, Caprylyl Glycol, 1,2-Hexanediol, Xanthan Gum, Hydroxyacetophenone, Pentylene Glycol, Butyrospermum Parkii (Shea) Butter, Xylitol, Tamarindus Indica Seed Gum, Hydrogenated Lecithin, Sodium Phytate, Nasturtium Officinale Flower/Leaf/Stem Extract, Phenethyl Alcohol, Equisetum Arvense Extract, Urtica Dioica (Nettle) Extract, Porphyridium Cruentum Extract, Disodium Phosphate, Sodium Phosphate, Sodium Hyaluronate, Citric Acid, Pentapeptide-59, Phenoxyethanol, Polysorbate 60, Ethylhexylglycerin, Sodium Chloride

Gently massage onto face and neck. Use daily AM & PM.


Always Tested on Sensitive Skin
Paraben-, Fragrance-, and Dye-Free
Dermatologist Approved
Leaping bunny logo Certified Cruelty Free

Clinical Trial Results

After 4 Weeks:

  • 87% Agree Skin Looks Rejuvenated*
  • 67% Smoother Skin*
  • Up to 100% Reduction in Redness*
  • Up to 57% More Elastic Skin*

*In a clinical study on 31 men and women

Why Dr. Rossi?

sensitive skin, special care

Dr. Rossi embarked on a mission to rethink skin care and create de-aging solutions appropriate for all, regardless of age, gender, or level of skin sensitivity. His goal: To combat the signs of skin aging while suppressing sensitization.

After treating both those patients battling cancer and those seeking cosmetic treatments, Dr. Rossi noticed that when his patients looked better, they felt better and healed more quickly. But his patients with sensitive skin couldn’t get the results they wanted because products in the market aggravated their sensitivity.

The Breakthrough

Dr. Rossi developed his landmark formulas with his proprietary Bio-Theriac® complex, which helps correct the visible effects of aging and environmental aggressors while reducing sensitization. Dr. Rossi’s formulas exclude the use of ingredients that neither support skin health nor aid in its appearance, such as irritants, fillers, and fragrance.

The result is a relentlessly perfected and tested, revolutionary line of luxury treatments that will reveal your healthiest looking, most vibrant skin regardless of your gender identity, complexion, or skin condition. 

NEXT-GENERATION MEDICAL-GRADE SKIN CARE

"Skin sensitivity is not just discomfort—it can be tied to one of the root causes of premature skin aging. What we put on our skin matters, so if a product causes irritation it’s a big red flag and you’re probably doing more harm than good to your skin. I created this line of clean, high-performing products to restore skin to its youthful, healthy look while remaining non-irritating and safe to use on all skin types, including on the skin conditions of my cancer patients. This type of medical-grade skin care has never been done before."

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average rating 4.6 out of 5
Based on 53 reviews
  • 5 Stars
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98% of reviewers would recommend this product to a friend
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53 Reviews
Reviewed by simone, from Italy
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
25 - 34
Rated 5 out of 5
Review posted

Not a common moisturizer, advice of a dermatologist!!

As a Dermatologist, I’ve tried so many products before this one, and I have to say that's sensational. Apply just a small amount and you can cover the whole face up to the neck. Unlike others, this product doesn't grease, no need to fill it with layers to get the result! My skin is much more toned and hydrated and much brighter! I also used it on chapped lips and it works very well there too. I would like to congratulate you on the product, which I will recommend to my patients in Italy!

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Reviewed by Christine L., from United States
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
25 - 34
Rated 5 out of 5
Review posted

Love this serum

This serum is the real deal. I have absolutely noticed a major difference in my skin - less redness and irritation and reduction in lines and wrinkles. I have had the deepest line in the middle of my eyebrows for as long as I can remember and it is practically gone!

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Reviewed by Phyllis B. , from United States
I recommend this product
Skin Type
Oily
Age Range
25 - 34
Rated 4 out of 5
Review posted

The proof is in the pudding!

The proof is sure in the pudding! This product delivers. I have always struggled with redness and after using this product for a while, I have noticed a significant improvement with my skin. My redness has calmed down and there is even a glow to my skin. I look and feel rejuvenated and hydrated! My friends and family have also noticed a difference. I highly recommend this product to everyone.

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Reviewed by Brittany W., from United States
Verified Reviewer
I recommend this product
Skin Type
Normal
Age Range
25 - 34
Rated 5 out of 5
Review posted

SO glad I purchased!

This product is something I look forward to using every single day, twice a day) ! The formulation is the perfect balance of light and moisturizing and I feel so good taking care of my skin with this product.

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Reviewed by Baylee, from United States
Verified Reviewer
I recommend this product
Rated 5 out of 5
Review posted

Powerful Yet Gentle

I was gifted by De. Rossi Derm MD. This is a powerful and clinical serum that works and you can tell. My skin felt smoother, looked less red, and overall improved. It is silky smooth and absorbs well into my skin. I noticed that my skin felt more plump and youthful. It hasn’t irritated me and has been great overall.

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