The Night Synthesis
closeup of smear of cream-colored skincare night cream, on white background
Bio-Theriac Complex: fights signs of again and sensitivity. Nasturtium officinale and urtica dioica extracts: help protect against environmental stressors. Squalane: moisturizes and restores elasticity.
Two images of a man&
Two side-by-side images of a woman&
female model with dark hair applying Dr. Rossi DERM MD night cream, set against starry night sky background
The Night Synthesis
The Night Synthesis
closeup of smear of cream-colored skincare night cream, on white background
Bio-Theriac Complex: fights signs of again and sensitivity. Nasturtium officinale and urtica dioica extracts: help protect against environmental stressors. Squalane: moisturizes and restores elasticity.
Two images of a man's brow from The Night Synthesis clinical trials. Image on the top displays man's brow before using The Night Synthesis, and the image on the bottom shows his brow after using The Night Synthesis for four weeks.
Two side-by-side images of a woman's cheek from The Night Synthesis clinical trials. Image on the left displays woman's cheek before using The Night Synthesis, and the image on the right shows her cheek after using The Night Synthesis for four weeks.
female model with dark hair applying Dr. Rossi DERM MD night cream, set against starry night sky background
The Night Synthesis

The Night Synthesis

Restructuring concentrate

Rated 4.7 out of 5
Based on 42 reviews
$198.00
/

Size
Description

This clinically proven age-defying concentrate harnesses the transformative power of Bio-Theriac® complex in a buttery texture that works with your skin while you sleep to visibly reduce the number and severity of fine lines and wrinkles while helping calm irritation.

Appropriate for all skin types, including sensitive, dry, combination, and oily.

Bio-Theriac® complex

Dr. Rossi’s proprietary ingredient composite harnesses the power of biomimetic sea anemone peptide, niacinamide, and hyaluronic acid in a unique, optimized ratio to help fight the visible signs of premature aging caused by sensitization in skin.

Nasturtium Officinale and Urtica Dioica Extracts

Studies show that these watercress and nettle leaf extracts have high antioxidant activity, helping shield skin against environmental stressors which can lead to premature aging.  

Squalane 

One of nature’s greatest emollients, this plant-based, lab-fermented squalane helps prevent moisture loss while helping smooth skin and restore elasticity.

All Ingredients: Aqua/Water/Eau, Ethylhexyl Olivate, Cocos Nucifera (Coconut) Oil, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Niacinamide, Glycerin, Cetyl Alcohol, Glyceryl Stearate Citrate, Butylene Glycol, Persea Gratissima (Avocado) Oil, Maltodextrin, Polyglyceryl-3 Stearate, Hydrogenated Lecithin, Caprylyl Glycol, 1,2-Hexanediol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Squalane, Hydroxyacetophenone, Sodium Hyaluronate, Sodium Hydroxide, Sodium Phytate, Nasturtium Officinale Flower/Leaf/Stem Extract, Phenethyl Alcohol, Equisetum Arvense Extract, Urtica Dioica (Nettle) Extract, Pentapeptide-59, Tocopherol, Ethylhexylglycerin, Sodium Chloride

Gently massage onto face and neck before bed. Use nightly.


Always Tested on Sensitive Skin
Paraben-, Fragrance-, and Dye-Free
Dermatologist Approved
Leaping bunny logo Certified Cruelty Free

Clinical Trial Results

After 4 Weeks:

  • 87% Agree Skin Feels More Supple and Elastic*
  • 87% Agree Skin Feels Healthier and Energized*
  • Up to 100% Smoother Skin*
  • Up to 100% Reduction in Redness*

*In a clinical study on 31 men and women 

Why Dr. Rossi?

sensitive skin, special care

Dr. Rossi embarked on a mission to rethink skin care and create de-aging solutions appropriate for all, regardless of age, gender, or level of skin sensitivity. His goal: To combat the signs of skin aging while suppressing sensitization.

After treating both those patients battling cancer and those seeking cosmetic treatments, Dr. Rossi noticed that when his patients looked better, they felt better and healed more quickly. But his patients with sensitive skin couldn’t get the results they wanted because products in the market aggravated their sensitivity.

The Breakthrough

Dr. Rossi developed his landmark formulas with his proprietary Bio-Theriac® complex, which helps correct the visible effects of aging and environmental aggressors while reducing sensitization. Dr. Rossi’s formulas exclude the use of ingredients that neither support skin health nor aid in its appearance, such as irritants, fillers, and fragrance.

The result is a relentlessly perfected and tested, revolutionary line of luxury treatments that will reveal your healthiest looking, most vibrant skin regardless of your gender identity, complexion, or skin condition. 

NEXT-GENERATION MEDICAL-GRADE SKIN CARE

"Skin sensitivity is not just discomfort—it can be tied to one of the root causes of premature skin aging. What we put on our skin matters, so if a product causes irritation it’s a big red flag and you’re probably doing more harm than good to your skin. I created this line of clean, high-performing products to restore skin to its youthful, healthy look while remaining non-irritating and safe to use on all skin types, including on the skin conditions of my cancer patients. This type of medical-grade skin care has never been done before."

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Write a Review
average rating 4.7 out of 5
Based on 42 reviews
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42 Reviews
Reviewed by Tina, from United States
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
35 - 44
Rated 4 out of 5
Review posted

expensive but effective

Dr. Rossi Derm MD gifted me the Night Synthesis Synthesis Concentrate for reviewing purposes and I was skeptical at first.

This is my first time trying the brand and when the price tags are this high, the moisturizer has to be special. And to me it was.

The ingredient list (which features both hydrating and moisturizing components) is impressive and I also really enjoy the texture. It is soft and creamy yet substantial and also absorbs really well with no greasy residue. My skin feels replenished and smooth in the mornings (I use this as my p.m. moisturizer).

The price tag is still high but if you are up for a splurge, this one is a good moisturizer to splurge on.

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Reviewed by Cat, from United States
I recommend this product
Skin Type
Combination
Age Range
25 - 34
Rated 5 out of 5
Review posted

Rich and moisturizing!!

Absolutely love this night cream. It’s rich and thick providing the skin with so much moisture and hydration. Definitely keeps my skin supple and my fine lines hydrated through the next morning. New fav in my nighttime routine. Gifted by Dr. Rossi Derm MD.

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Reviewed by Victoria, from United States
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
25 - 34
Rated 5 out of 5
Review posted

So luxurious!

I am in love with this night cream! It’s super thick and a little bit goes a long, long way without feeling too heavy. My face doesn’t feel greasy, but instead feels hydrated and happy after application. I’ve been using it for a couple weeks yet and I don’t have any existing issues with fine lines or wrinkles, but my face feels and looks nice and smooth. If this is in your budget, it’s definitely worth the splurge! I received it complimentary from Dr. Rossi Derm MD.

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Reviewed by embrg20, from United States
Verified Reviewer
I recommend this product
Skin Type
Dry
Age Range
25 - 34
Rated 4 out of 5
Review posted

Rich and buttery

The Night Synthesis is a really rich texture that feels really nice on my dry skin. I use it as the last step in my nightly skincare routine, and sometimes mix in some extras like an oil or retinol. This cream is an emollient, so it’s very thick and sometimes makes my eyebrows feel like they’ve been glued down (lol), but it’s definitely a nighttime product!

Gifted by Dr. Rossi Derm MD

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Reviewed by Kati H., from United States
I recommend this product
Rated 5 out of 5
Review posted

Rich and Effective

LOVE this product - it is thick and powerful, so you don't need a lot. My skin felt extremely moisturized and nourished the next day. Absolutely love and will continue to use for my fine lines and to fight the signs of aging.

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