The Night Synthesis
closeup of smear of cream-colored skincare night cream, on white background
Bio-Theriac Complex: fights signs of again and sensitivity. Nasturtium officinale and urtica dioica extracts: help protect against environmental stressors. Squalane: moisturizes and restores elasticity.
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female model with dark hair applying Dr. Rossi DERM MD night cream, set against starry night sky background
The Night Synthesis

The Night Synthesis

Restructuring concentrate

Rated 4.7 out of 5
Based on 46 reviews
Regular price Sale price $198.00
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Size
Description

This clinically proven age-defying concentrate harnesses the transformative power of Bio-Theriac® complex in a buttery texture that works with your skin while you sleep to visibly reduce the number and severity of fine lines and wrinkles while helping calm irritation.

Appropriate for all skin types, including sensitive, dry, combination, and oily.

Bio-Theriac® complex

Dr. Rossi’s proprietary ingredient composite harnesses the power of biomimetic sea anemone peptide, niacinamide, and hyaluronic acid in a unique, optimized ratio to help fight the visible signs of premature aging caused by sensitization in skin.

Nasturtium Officinale and Urtica Dioica Extracts

Studies show that these watercress and nettle leaf extracts have high antioxidant activity, helping shield skin against environmental stressors which can lead to premature aging.  

Squalane 

One of nature’s greatest emollients, this plant-based, lab-fermented squalane helps prevent moisture loss while helping smooth skin and restore elasticity.

All Ingredients: Aqua/Water/Eau, Ethylhexyl Olivate, Cocos Nucifera (Coconut) Oil, Cetearyl Alcohol, Butyrospermum Parkii (Shea) Butter, Niacinamide, Glycerin, Cetyl Alcohol, Glyceryl Stearate Citrate, Butylene Glycol, Persea Gratissima (Avocado) Oil, Maltodextrin, Polyglyceryl-3 Stearate, Hydrogenated Lecithin, Caprylyl Glycol, 1,2-Hexanediol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Squalane, Hydroxyacetophenone, Sodium Hyaluronate, Sodium Hydroxide, Sodium Phytate, Nasturtium Officinale Flower/Leaf/Stem Extract, Phenethyl Alcohol, Equisetum Arvense Extract, Urtica Dioica (Nettle) Extract, Pentapeptide-59, Tocopherol, Ethylhexylglycerin, Sodium Chloride

Gently massage onto face and neck before bed. Use nightly.


Always Tested on Sensitive Skin
Paraben-, Fragrance-, and Dye-Free
Dermatologist Approved
Leaping bunny logo Certified Cruelty Free

Clinical Trial Results

Why Dr. Rossi?

sensitive skin, special care

Dr. Rossi embarked on a mission to rethink skin care and create de-aging solutions appropriate for all, regardless of age, gender, or level of skin sensitivity. His goal: To combat the signs of skin aging while suppressing sensitization.

After treating both those patients battling cancer and those seeking cosmetic treatments, Dr. Rossi noticed that when his patients looked better, they felt better and healed more quickly. But his patients with sensitive skin couldn’t get the results they wanted because products in the market aggravated their sensitivity.

The Breakthrough

Dr. Rossi developed his landmark formulas with his proprietary Bio-Theriac® complex, which helps correct the visible effects of aging and environmental aggressors while reducing sensitization. Dr. Rossi’s formulas exclude the use of ingredients that neither support skin health nor aid in its appearance, such as irritants, fillers, and fragrance.

The result is a relentlessly perfected and tested, revolutionary line of luxury treatments that will reveal your healthiest looking, most vibrant skin regardless of your gender identity, complexion, or skin condition. 

NEXT-GENERATION MEDICAL-GRADE SKIN CARE

"Skin sensitivity is not just discomfort—it can be tied to one of the root causes of premature skin aging. What we put on our skin matters, so if a product causes irritation it’s a big red flag and you’re probably doing more harm than good to your skin. I created this line of clean, high-performing products to restore skin to its youthful, healthy look while remaining non-irritating and safe to use on all skin types, including on the skin conditions of my cancer patients. This type of medical-grade skin care has never been done before."

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average rating 4.7 out of 5
Based on 46 reviews
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46 Reviews
Reviewed by Emily, from United States
Verified Buyer
I recommend this product
Skin Type
Normal
Age Range
35 - 44
Rated 5 out of 5
Review posted

Prefect for that deep moisturizing!

I started using this product while my skin was peeling and dried out-- it has become my GO TO when I see some skin that needs extra TLC at night :)

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Reviewed by Lina, from United States
I recommend this product
Skin Type
Dry
Age Range
35 - 44
Rated 5 out of 5
Review posted

The magic cream

The texure of this cream is everything i been looking for! It does wonders overnight and really work its magic. Be aware-addictive! Its a 10 out of 10!!

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Reviewed by Christine L., from United States
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
25 - 34
Rated 5 out of 5
Review posted

My favorite product

This nighttime moisturizer is a game changer. It’s thick without being too heavy. It soaks into your skin overnight and leaves you feeling soft and hydrated in the morning. I absolutely love this product. It really feels like my skin is repairing overnight and it’s nice and refreshed when I wake up. When I use this with the eye cream I feel like a new person in the morning.

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Reviewed by Mary C., from United States
Verified Buyer
I recommend this product
Skin Type
Sensitive
Age Range
65+
Rated 5 out of 5
Review posted

Excellent

Very nourishing without being oily.

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Reviewed by Tina, from United States
Verified Reviewer
I recommend this product
Skin Type
Combination
Age Range
35 - 44
Rated 4 out of 5
Review posted

expensive but effective

Dr. Rossi Derm MD gifted me the Night Synthesis Synthesis Concentrate for reviewing purposes and I was skeptical at first.

This is my first time trying the brand and when the price tags are this high, the moisturizer has to be special. And to me it was.

The ingredient list (which features both hydrating and moisturizing components) is impressive and I also really enjoy the texture. It is soft and creamy yet substantial and also absorbs really well with no greasy residue. My skin feels replenished and smooth in the mornings (I use this as my p.m. moisturizer).

The price tag is still high but if you are up for a splurge, this one is a good moisturizer to splurge on.

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